Published: 4 December 2025

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Test your knowledge: the Prescriber Update quiz 2025

Published: 4 December 2025
Prescriber Update 46(4): 61–62
December 2025

Have you been reading Prescriber Update in 2025?

Have you kept up to date with emerging safety signals?

Test your knowledge with the end-of-year Prescriber Update quiz.

1. The use of Contrave (naltrexone + bupropion) is contraindicated in which of the following patients?
   1. A patient with controlled hypertension and a BMI of 32
   2. A patient receiving opioid substitution therapy
   3. A patient with a history of smoking and mild depression
   4.  A patient with well-managed type 2 diabetes and no psychiatric history
2. True or false: Fluoroquinolone-induced tendon rupture can occur months after stopping treatment.
3. How long after starting immunotherapy does immune effector cell-associated neurotoxicity syndrome (ICANS) usually occur?
4. A patient on long-term systemic retinoid therapy starts to experience musculoskeletal problems, including back pain, morning stiffness and reduced range of motion. What condition may have developed?
5. What advice should be given to patients starting on GLP-1 receptor agonists to reduce the risk of acute renal injury?
6. Which of the following statements about colchicine is false?
   1. Reduce the colchicine dose by half if the patient’s creatinine clearance is ≤10 mL/min
   2. Itraconazole, clarithromycin, verapamil and amiodarone can interact with colchicine
   3. Colchicine may increase the risk of bleeding in patients taking anticoagulants
   4. The first signs of colchicine toxicity may be a feeling of burning and rawness in the mouth and throat and difficulty in swallowing
7. What is the mechanism for paracetamol-induced high anion gap metabolic acidosis (HAGMA)?
   1. 5-oxoproline depletion due to low glutathione levels
   2. 5-oxoproline accumulation due to high glutathione levels
   3. Pyroglutamate accumulation due to low glutathione levels
   4. Pyroglutamate depletion due to high glutathione levels
8. Is cholestatic jaundice typically associated with short or long term use of nitrofurantoin?
9. A 45-year-old woman presents with intermittent abdominal pain, nausea and vomiting. Imaging shows bowel wall thickening and mild ascites. Of the medicines listed below that she is taking, which is the most likely to have caused this?
   1. Paracetamol
   2. Levonorgestrel
   3. Perindopril
   4. Gabapentin
10. A couple is considering starting a family but one of them is taking methotrexate. How long after stopping methotrexate should they continue to use contraception for?
    1. At least 3 months after stopping for males and at least 3 months for females
    2. At least 6 months after stopping for males and at least 6 months for females
    3. At least 6 months after stopping for males and at least 3 months for females
    4. At least 3 months after stopping for males and at least 6 months for females

Click here for quiz answers