Published: December 2012


Bupropion (Zyban): Association with Congenital Malformations?

This article is more than five years old. Some content may no longer be current.

Prescriber Update 33(4):33
December 2012

Data from a recent epidemiological study shows a possible increased risk of congenital cardiovascular malformations after exposure to bupropion (Zyban) in the first trimester of pregnancy. All women who are pregnant or planning to become pregnant should be informed of this potential risk associated with bupropion treatment. The bupropion data sheet is being updated to provide more information on this potential risk. The Zyban data sheet is available at

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