1.

MATTERS OF ADMINISTRATION

1.1

Welcome and apologies

1.2

Minutes and recommendations of the 194th MARC meeting

1.3

Declarations of potential competing interests

2.

MATTERS ARISING FROM THE NZ PHARMACOVIGILANCE CENTRE

2.1

CARM quarterly report

3.

PHARMACOVIGILANCE REPORTS

3.1

Matters referred to the MARC under section 36 of the Medicines Act 1981

No items

3.2

Matters referred to the MARC by Medsafe

3.2.1 Oral lidocaine containing products and risks of toxicity in younger children and infants

3.2.2 DPP-4 inhibitors and GLP-1 receptor agonists and the risk of intestinal obstruction

3.2.3  Acetylcholinesterase inhibitors and the risk QT prolongation and Torsades de Pointes

3.2.4  Isotretinoin – psychiatric disorders and sexual dysfunction

4.

MEDSAFE PHARMACOVIGILANCE ACTIVITIES

4.1

Report on standing agenda items

4.2

Medsafe pharmacovigilance activities

4.3

Prescriber Update

4.4

Quarterly summary of recent safety communications