Published: August 2009

Nitrous oxide - side effects reminder

Prescriber Update 30(3): 20
August 2009

Prescribers are reminded that prolonged use of nitrous oxide has been associated with neurological and haematological side effects such as megaloblastic anaemia and myelopathy due to inactivation of vitamin B12. Neurological symptoms can occur without any overt haematological changes.

Where possible, prescribers are advised: