Published: 1 March 2018
Publications
Gathering Knowledge from Adverse Reaction Reports: Mar 2018
Prescriber Update 39(1): 13
March 2018
Adverse reaction reporting is an important component of medicine safety monitoring. Case reports can highlight significant safety issues concerning therapeutic products and their use.
A selection of recent informative cases from the Centre for Adverse Reactions Monitoring (CARM) database is presented below.
CARM ID: 125952 Age: 60 Gender: Female Medicine(s): Ciprofloxacin Reaction(s): Anxiety, Agitation, Paranoid thoughts |
A 60-year-old patient experienced anxiety, agitation and paranoid thoughts one day after taking ciprofloxacin. |
The Cipflox data sheet (www.medsafe.govt.nz/profs/Datasheet/c/Cipfloxtabinf.pdf) states that psychiatric reactions may occur even after the first administration of fluoroquinolones, including ciprofloxacin. In these cases, ciprofloxacin should be discontinued and the appropriate measures instituted. | |
CARM ID: 125838 Age: 23 Gender: Male Medicine(s): Paracetamol Reaction(s): Steven Johnson Syndrome (SJS) |
A 23-year-old male took several medicines and experienced wide spread ulcers on the tongue, mouth, lips with angioedema. Upon dermatologist review, paracetamol was identified as the most likely cause. |
The data sheet for Panadol (www.medsafe.govt.nz/profs/Datasheet/p/panadoltab.pdf) lists Stevens-Johnson Syndrome as a very rare adverse reaction. | |
CARM ID: 125845 Age: 70 Gender: Female Medicine(s): Zoledronic acid and others Reaction(s): Osteonecrosis of both ear canals |
The patient was being treated with zoledronate infusions and was found to have osteonecrosis of both ear canals that was successfully treated. |
The data sheet for Aclasta (www.medsafe.govt.nz/profs/Datasheet/a/Aclastainf.pdf) states that cases of osteonecrosis of bones other than the jaw have been reported. |