Published: September 2011

Updated advice: ceftriaxone and calcium precipitation

Prescriber Update 32(3): 26
September 2011

In February 2008, healthcare professionals were advised that ceftriaxone should not be mixed or administered with calcium containing solutions due to the risk of precipitation.

Following further investigation, the safety information for the use of ceftriaxone is now being updated with the following recommendations:

These recommendations follow Medsafe’s review of two in vitro studies to assess the potential for precipitation of ceftriaxone and calcium when mixed in infusion lines. The in vitro studies were conducted in neonatal and adult plasma; but only showed an increased risk in neonatal plasma.