Published: 2 June 2016

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Jadelle and the Impact of Weight

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Prescriber Update 37(2): 27

June 2016

Jadelle (levonorgestrel implants) is a contraceptive implant for long-term (up to five years) use and is one of the most effective methods of contraception.

The New Zealand data sheet for Jadelle states that the implants are effective for five years in women who weigh up to 60 kg and that the implants may be removed after four years in women who weigh over 60 kg¹.

In March 2016, the Medicines Adverse Reactions Committee (MARC) reviewed the current data on the weight-based efficacy of Jadelle². The MARC considered that the available evidence suggests a reduction in the efficacy of levonorgestrel with increasing body weight over time. However, the current information is insufficient to determine at what time point efficacy may be reduced.

Healthcare professionals are asked to discuss the replacement time for Jadelle with patients before insertion. Women over 60 kg may wish to replace their Jadelle implants earlier than five years.

Please report any adverse events, including unintended pregnancy with Jadelle, to the Centre for Adverse Reactions Monitoring (CARM). It is particularly helpful if the patient's weight and body mass index (BMI) at insertion and later time points are included in your report (https://nzphvc.otago.ac.nz/carm/).

References

1. Bayer New Zealand Limited. 2015. Jadelle Data Sheet 9 September 2015. URL: www.medsafe.govt.nz/profs/datasheet/j/Jadelleimplant.pdf (accessed 21 March 2016).
2. Medsafe. 2016. Contraception with levonorgestrel subcutaneous implants (Jadelle) and weight-based efficacy. Minutes of the 165th Medicines Adverse Reactions Committee Meeting 10 March 2016. URL: www.medsafe.govt.nz/profs/adverse/Minutes165.htm (accessed 19 April 2016).